Skin-Nomad's Take — At a Glance
- 99% purity salmon DNA PDRN with collagen and Vitamin B12
- A close-fitting sheet that holds the essence against the skin
- One sheet, ten to twenty minutes, nothing to rinse off
PDRN came to skincare from clinical repair work, and the number that matters on the raw material is its purity, because a polynucleotide fraction is only as good as what has been refined out of it. Medicube state 99% purity salmon DNA PDRN in this mask, carried in a close-fitting sheet with collagen, Vitamin B12 and Niacinamide. Medicube formulates in South Korea around measured, results-led skincare, and this is the sheet-mask step of its PDRN Pink range.
Key Benefits
- 99% purity describes the PDRN itself, and it is the figure to compare. Salmon DNA PDRN is refined from salmon milt, and purity states how much of the extracted fraction is polynucleotide rather than residual protein and lipid left behind by the process. A higher-purity fraction is the cleaner and better-characterised raw material, which is why brands publish the number and why it is the one worth reading across PDRN products.
- Polynucleotides work on hydration and skin renewal. They hold water in the upper layers and are studied for their effect on the skin's own repair activity, which is the combination the whole PDRN category is built on. Most of the evidence behind it comes from clinical and injectable use, and topical formats are the newer and fastest-moving half of that field.
- Collagen and Vitamin B12 complete the Pink Vita pairing. Soluble collagen holds water at the surface for a plumper, better-cushioned finish, while Cyanocobalamin, the B12 of the name, is a deep pink compound and part of why the essence looks the way it does.
- Niacinamide and Adenosine work underneath on tone and firmness. Niacinamide limits how much melanin reaches the surface and prompts the skin to make more of its own ceramides, and Adenosine is listed by Korea's Ministry of Food and Drug Safety as an approved functional ingredient for firmness and smoothness. Both build across repeated use rather than in one sitting.
Texture & Finish
The essence is thin and runs freely, and the sheet comes out saturated rather than merely damp. It sits close enough to stay put while you move around, and what is left behind absorbs within a minute or two with no tack and no rinsing.
Medicube's own testing, carried out by the Global Institute of Dermatological Sciences, recorded skin radiance up 34.8% and deep surface hydration up 163.59% after use. The brand notes that results vary between individuals.
Note: The PDRN here is salmon-derived, which is the original and most-studied source, and it means the formula is not plant-only. If that matters to you, our vegan PDRN edit covers the plant and ferment-derived alternatives. There is fragrance in the formula as well.
Ideal For
- Skin types: All skin types, and normal, dry and combination skin in particular.
- Skin concerns: Hydration, dullness, uneven tone, and firmness over time.
- Best used by: People already using a PDRN serum or cream who want the same active in a weekly step, and anyone wanting to try the category before committing to a full-size bottle.
FAQ
Q: What does 99% purity actually mean?
A: It describes the raw ingredient rather than how much of it is in the mask. PDRN is refined from salmon milt, and the refining separates the polynucleotide fraction from the protein and lipid it arrives with. A 99% figure means almost all of what goes in is the polynucleotide itself. It is a quality grade, and it is the number that lets you compare one PDRN product with another, since concentration is rarely published by anyone.
Q: How does a PDRN sheet mask compare with a PDRN serum?
A: A serum is the daily version and a mask is the concentrated one. A sheet holds a much larger volume of essence pressed against the skin and stops it evaporating, so a single sitting delivers more than one application of a serum would. What it cannot do is match the cumulative effect of something you use every night, which is why the two work better together than as alternatives.
Q: Where does it sit in a routine, and how often?
A: After cleansing and any toner, before your serum and moisturiser. Leave it on for ten to twenty minutes, take it off, and press the rest in rather than rinsing. Once or twice a week suits most people, and it layers over a PDRN serum without any conflict.
A purity grade printed on the box tells you more about what you are actually buying than most of what sits beside it.
Explore more
Browse more masks and peels, or see more from Medicube.
Skin-Nomad's Take — At a Glance
- 99% purity salmon DNA PDRN with collagen and Vitamin B12
- A close-fitting sheet that holds the essence against the skin
- One sheet, ten to twenty minutes, nothing to rinse off
PDRN came to skincare from clinical repair work, and the number that matters on the raw material is its purity, because a polynucleotide fraction is only as good as what has been refined out of it. Medicube state 99% purity salmon DNA PDRN in this mask, carried in a close-fitting sheet with collagen, Vitamin B12 and Niacinamide. Medicube formulates in South Korea around measured, results-led skincare, and this is the sheet-mask step of its PDRN Pink range.
Key Benefits
- 99% purity describes the PDRN itself, and it is the figure to compare. Salmon DNA PDRN is refined from salmon milt, and purity states how much of the extracted fraction is polynucleotide rather than residual protein and lipid left behind by the process. A higher-purity fraction is the cleaner and better-characterised raw material, which is why brands publish the number and why it is the one worth reading across PDRN products.
- Polynucleotides work on hydration and skin renewal. They hold water in the upper layers and are studied for their effect on the skin's own repair activity, which is the combination the whole PDRN category is built on. Most of the evidence behind it comes from clinical and injectable use, and topical formats are the newer and fastest-moving half of that field.
- Collagen and Vitamin B12 complete the Pink Vita pairing. Soluble collagen holds water at the surface for a plumper, better-cushioned finish, while Cyanocobalamin, the B12 of the name, is a deep pink compound and part of why the essence looks the way it does.
- Niacinamide and Adenosine work underneath on tone and firmness. Niacinamide limits how much melanin reaches the surface and prompts the skin to make more of its own ceramides, and Adenosine is listed by Korea's Ministry of Food and Drug Safety as an approved functional ingredient for firmness and smoothness. Both build across repeated use rather than in one sitting.
Texture & Finish
The essence is thin and runs freely, and the sheet comes out saturated rather than merely damp. It sits close enough to stay put while you move around, and what is left behind absorbs within a minute or two with no tack and no rinsing.
Medicube's own testing, carried out by the Global Institute of Dermatological Sciences, recorded skin radiance up 34.8% and deep surface hydration up 163.59% after use. The brand notes that results vary between individuals.
Note: The PDRN here is salmon-derived, which is the original and most-studied source, and it means the formula is not plant-only. If that matters to you, our vegan PDRN edit covers the plant and ferment-derived alternatives. There is fragrance in the formula as well.
Ideal For
- Skin types: All skin types, and normal, dry and combination skin in particular.
- Skin concerns: Hydration, dullness, uneven tone, and firmness over time.
- Best used by: People already using a PDRN serum or cream who want the same active in a weekly step, and anyone wanting to try the category before committing to a full-size bottle.
FAQ
Q: What does 99% purity actually mean?
A: It describes the raw ingredient rather than how much of it is in the mask. PDRN is refined from salmon milt, and the refining separates the polynucleotide fraction from the protein and lipid it arrives with. A 99% figure means almost all of what goes in is the polynucleotide itself. It is a quality grade, and it is the number that lets you compare one PDRN product with another, since concentration is rarely published by anyone.
Q: How does a PDRN sheet mask compare with a PDRN serum?
A: A serum is the daily version and a mask is the concentrated one. A sheet holds a much larger volume of essence pressed against the skin and stops it evaporating, so a single sitting delivers more than one application of a serum would. What it cannot do is match the cumulative effect of something you use every night, which is why the two work better together than as alternatives.
Q: Where does it sit in a routine, and how often?
A: After cleansing and any toner, before your serum and moisturiser. Leave it on for ten to twenty minutes, take it off, and press the rest in rather than rinsing. Once or twice a week suits most people, and it layers over a PDRN serum without any conflict.
A purity grade printed on the box tells you more about what you are actually buying than most of what sits beside it.
Explore more
Browse more masks and peels, or see more from Medicube.
