What Is PDRN?
PDRN (Polydeoxyribonucleotide) is one of the most exciting ingredients to emerge from Korean dermatology clinics and make its way into premium skincare. Derived from salmon DNA, PDRN has been used in Korean medical aesthetics for years to promote skin regeneration and healing. Now, this clinically-proven ingredient is available in topical formulations, bringing professional-grade skin repair to your daily routine.
At Skin-Nomad, we've seen firsthand how PDRN products—particularly the Medicube PDRN Pink Collagen Capsule Cream—have become customer favourites for their visible results in firming, brightening, and restoring skin vitality.
How Does PDRN Work?
PDRN works at a cellular level to support your skin's natural regeneration processes:
- Stimulates collagen production: PDRN activates fibroblasts, the cells responsible for producing collagen and elastin, helping to firm and plump the skin
- Enhances skin regeneration: It promotes cellular turnover and repair, making it excellent for post-procedure recovery or damaged skin barriers
- Reduces inflammation: PDRN has anti-inflammatory properties that calm irritation and redness
- Improves microcirculation: Better blood flow means more nutrients and oxygen reach your skin cells, resulting in a healthier, more radiant complexion
- Strengthens the skin barrier: By supporting cellular repair, PDRN helps restore and maintain a resilient moisture barrier
Clinical PDRN vs Topical PDRN: What's the Difference?
You may have heard of PDRN injections offered in dermatology clinics. These injectable treatments deliver PDRN directly into the dermis for intensive skin rejuvenation, often used for acne scarring, post-laser recovery, or advanced anti-ageing.
Topical PDRN products—like the Medicube PDRN Pink Peptide Serum and PDRN Pink Collagen Capsule Cream—work on the skin's surface and upper layers. While they don't penetrate as deeply as injections, they still deliver impressive benefits: improved texture, enhanced firmness, barrier repair, and a visible glow. The advantage? You can use them daily at home as part of your routine, with no downtime or clinic visits required.
The Benefits of PDRN Skincare
PDRN is a multi-tasking powerhouse suitable for a wide range of skin concerns:
- Anti-ageing: Boosts collagen and elastin for firmer, more youthful-looking skin
- Brightening: Improves skin tone and radiance by supporting healthy cell turnover
- Barrier repair: Ideal for sensitised, compromised, or dehydrated skin
- Post-treatment recovery: Speeds healing after professional treatments like peels, microneedling, or laser
- Texture refinement: Smooths rough, uneven skin and minimises the appearance of pores
- Hydration support: Works synergistically with hyaluronic acid and ceramides to lock in moisture
How to Use PDRN Products in Your Routine
PDRN products are versatile and can be used both morning and night, depending on the formulation:
Morning Routine
- Cleanse
- Apply PDRN Pink Cica Soothing Toner or PDRN Pink Collagen Toning Gel Toner Pad
- Layer PDRN Pink Peptide Serum for targeted repair
- Moisturise with PDRN Pink Hyaluronic Moisturizing Cream
- Finish with SPF (essential to protect regenerating skin)
Night-time Routine
- Double cleanse
- Apply toner
- Use PDRN Pink Peptide Serum
- Apply PDRN Pink Peptide Eye Cream around the eye area
- Seal with PDRN Pink Collagen Capsule Cream for overnight repair
- Use PDRN Pink Collagen Gel Mask 2-3 times per week for an intensive boost
Layering with Other Actives
PDRN plays well with most ingredients. You can safely combine it with:
- Hyaluronic acid: For enhanced hydration
- Niacinamide: For brightening and barrier support
- Peptides: For synergistic anti-ageing benefits (many Medicube PDRN products already contain peptides)
- Retinol: Use retinol on alternate nights or apply PDRN first, wait 10-15 minutes, then apply retinol
Avoid using PDRN immediately after strong exfoliating acids (AHAs/BHAs) or vitamin C to prevent potential irritation.
Who Should Use PDRN?
PDRN is suitable for all skin types, but it's particularly beneficial for:
- 30s and beyond: Those looking for effective anti-ageing and collagen support
- Sensitive or reactive skin: PDRN's anti-inflammatory properties make it gentle yet effective
- Barrier-compromised skin: If your skin feels tight, irritated, or dehydrated
- Post-treatment care: After professional treatments or when recovering from skin damage
- Anyone seeking firmer, more radiant skin: PDRN delivers visible improvements in texture and luminosity
Featured PDRN Products at Skin-Nomad
We're proud to offer the complete Medicube PDRN Pink range, which has quickly become one of our bestselling collections:
- PDRN Pink Collagen Capsule Cream: Our #1 bestseller. This rich, nourishing cream combines PDRN with collagen and peptides for intensive overnight repair and firming
- PDRN Pink Peptide Serum: A lightweight, fast-absorbing serum that delivers concentrated PDRN deep into the skin for maximum regeneration
- PDRN Pink Collagen Gel Mask: A cooling gel mask for weekly intensive treatment—perfect for prepping skin before events or recovering after sun exposure
- PDRN Pink Peptide Eye Cream: Targets fine lines, dark circles, and puffiness around the delicate eye area
- PDRN Pink Cica Soothing Toner: Preps and calms skin while delivering PDRN benefits from the first step
- Complete PDRN Pink Routine: Get the full system for comprehensive skin transformation
PDRN vs Other Trending Ingredients
| Ingredient | Primary Benefit | Best For | When to Choose PDRN Instead |
|---|---|---|---|
| Retinol | Cell turnover, anti-ageing | Fine lines, texture, pigmentation | If you have sensitive skin or want barrier repair alongside anti-ageing |
| Peptides | Collagen support, firming | Loss of firmness, fine lines | PDRN offers more comprehensive regeneration; many PDRN products contain peptides too |
| Niacinamide | Brightening, barrier support | Uneven tone, enlarged pores | When you need deeper cellular repair and anti-inflammatory benefits |
| Vitamin C | Brightening, antioxidant | Dullness, pigmentation, prevention | For regeneration and repair rather than just prevention |
The bottom line: PDRN excels at cellular regeneration and repair, making it ideal when your skin needs healing, barrier support, or comprehensive anti-ageing beyond surface-level improvements.
Frequently Asked Questions About PDRN
Is PDRN vegan?
No, PDRN is derived from salmon DNA, so it is not suitable for vegans. However, it is sustainably sourced from salmon milt (sperm) as a by-product of the fishing industry.
Is PDRN safe?
Yes, PDRN has been used safely in medical and aesthetic treatments for decades. Topical PDRN products are well-tolerated by most skin types, including sensitive skin. As with any new ingredient, patch-test first if you have concerns.
How long does it take to see results?
Many users notice improved hydration and radiance within 1-2 weeks. For firming, texture refinement, and anti-ageing benefits, expect to see visible results after 4-8 weeks of consistent use.
Can I use PDRN with retinol?
Yes! PDRN can actually help mitigate retinol irritation thanks to its barrier-repairing and anti-inflammatory properties. Use them on alternate nights, or apply PDRN first, wait 10-15 minutes, then apply retinol.
Can I use PDRN if I'm pregnant or breastfeeding?
While PDRN is generally considered safe, we always recommend consulting your healthcare provider before introducing new skincare ingredients during pregnancy or breastfeeding.
What's the difference between the PDRN Capsule Cream and the PDRN Serum?
The PDRN Pink Peptide Serum is a lightweight, concentrated treatment that absorbs quickly and works deeper in the skin. The PDRN Pink Collagen Capsule Cream is a richer moisturiser that seals in hydration and provides overnight repair. For best results, use both: serum first, then cream.
Do I need to refrigerate PDRN products?
No, but storing them in a cool, dark place will help maintain their efficacy. Some people enjoy refrigerating the PDRN Pink Collagen Gel Mask for an extra cooling, de-puffing effect.
Why PDRN Is the Ingredient to Watch in 2026
The UK skincare market is experiencing explosive growth in PDRN products, with search interest up 153% year-over-year. As consumers become more ingredient-savvy and seek clinically-proven, results-driven formulations, PDRN stands out as a scientifically-backed ingredient with visible benefits.
At Skin-Nomad, we're committed to bringing you the most effective, innovative ingredients from Korean beauty. Our Medicube PDRN Pink collection represents the perfect intersection of clinical efficacy and luxurious self-care.
Ready to experience the transformative power of PDRN? Explore our full range and discover why this ingredient is revolutionising skincare routines across the Globe.
